反应详情

Add potassium carbonate (0.138 g, 1 mmol) to a solution of 3-trimethylsilanylethynylbenzonitrile from PREPARATION 5 (2.0 g, 10.1 mmol) in methanol (50 mL). Stir the mixture at room temperature for 20 min and add a 10% aqueous hydrochloric acid solution (4 mL). Concentrate to a reduced volume, add diethyl ether and water and separate the phases. Wash once the aqueous phase with diethyl ether. Combine the organic phases, dry over sodium sulfate and concentrate to obtain the title compound as a solid (1.17 g, 92%).

1. concentrationConcentrate to a reduced volume
2. additionadd diethyl ether and water
3. customseparate the phases
4. washWash once the aqueous phase with diethyl ether
5. dry with materialdry over sodium sulfate
6. concentrationconcentrate