Potassium Carbonate → 5-(4-Fluorophenylethynyl)-pyridine-3-carbaldehyde oxime hydrochloride

HRID 606878ノート

反応式

HRID 606878 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:11]=[C:12]([CH:16]=O)[CH:13]=[N:14][CH:15]=2)=[CH:4][CH:3]=1.[ClH:18].[NH2:19][OH:20].C(=O)([O-])[O-].[K+].[K+]>>[ClH:18].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:11]=[C:12]([CH:16]=[N:19][OH:20])[CH:13]=[N:14][CH:15]=2)=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 860764705-(4-Fluorophenylethynyl)-pyridine-3-carbaldehyde

生成物 1

HCID 866224755-(4-Fluorophenylethynyl)-pyridine-3-carbaldehyde oxime hydrochloride収率 50.8%

実験手順

Prepare in a similar manner as described in EXAMPLE 6 using 5-(4-fluorophenylethynyl)-pyridine-3-carbaldehyde (150 mg, 0.64 mmol), (prepared essentially as described in EXAMPLE 99), hydroxylamine hydrochloride (360 mg, 5.15 mmol) and potassium carbonate (440 mg, 3.22 mmol) to give the title compound (90 mg, 50%).

後処理

  1. customPrepare in a similar manner
  2. custom(prepared essentially

出典と根拠

ORDレコード
ord-d059ff1a646243348ab9c23071fd09c6
出典データセット
uspto-grants-2011_03
特許番号
US07915424B2

反応ノート

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