Sodium Iodide → Benzonitrile, 4-[(5-iodopentyl)oxy]-

HRID 6069

反応式

HRID 6069 の反応式
Cl[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][CH:9]=1.[I-:16].[Na+]>CC(C)=O>[I:16][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 193815104-((5-Chloropentyl)oxy)benzonitrile

生成物 1

HCID 16202445Benzonitrile, 4-[(5-iodopentyl)oxy]-

試薬・触媒・溶媒 1

HCID 180Acetone溶媒2 回

実験手順

To a solution of 32.7 g (146 mmol) of 4-(5-chloropentoxy) benzonitrile in 350 mL acetone is added 38.3 g (150 mmol) of sodium iodide in 230 mL of acetone. The reaction is heated to reflux and stirred overnight. The acetone is removed under reduced pressure and the residue partitioned between water and ether. The ethereal layer is dried, filtered and evaporated to give 4-(5-iodopentoxy) benzonitrile, m.p. 51°-54° C.

後処理

  1. temperatureThe reaction is heated
  2. temperatureto reflux
  3. customThe acetone is removed under reduced pressure
  4. customthe residue partitioned between water and ether
  5. customThe ethereal layer is dried
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-adbf3dc1a5cb462d9cbba9a96dc56869
出典データセット
uspto-grants-1993_09
特許番号
US05246965

関連ノート

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