2-Fluoro-5-trimethylsilanylethynyl-phenylamine → 5-(3-Amino-4-fluorophenylethynyl)-nicotinonitrile

HRID 606922

反応式

HRID 606922 の反応式
Br[C:2]1([CH:9]=[CH:8][CH:7]=[N:6][CH2:5]1)[C:3]#[N:4].[F:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]#[C:18][Si](C)(C)C)=[CH:13][C:12]=1[NH2:23]>>[NH2:23][C:12]1[CH:13]=[C:14]([C:17]#[C:18][C:8]2[CH:7]=[N:6][CH:5]=[C:2]([CH:9]=2)[C:3]#[N:4])[CH:15]=[CH:16][C:11]=1[F:10]

参加物

3

反応物 2

HCID 670476962-Fluoro-5-trimethylsilanylethynyl-phenylamineHCID 670477743-Bromonicotinonitrile

生成物 1

HCID 670478225-(3-Amino-4-fluorophenylethynyl)-nicotinonitrile収率 65%

実験手順

Prepare essentially as described in EXAMPLE 138 using 3-bromonicotinonitrile (3.4 g, 18.3 mmol) and 2-fluoro-5-trimethylsilanylethynyl-phenylamine, (prepared as described in PREPARATION 41), (3.8 g, 18.3 mmol) to give the title compound as a white solid (2.8 g, 65%).

後処理

  1. customPrepare essentially

出典と根拠

ORDレコード
ord-00547915240f429085bf9f6c5be4190d
出典データセット
uspto-grants-2011_03
特許番号
US07915424B2

関連ノート

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