Potassium Carbonate → 1-(5-Phenylethynyl-pyridin-3-yl)-ethanone oxime hydrochloride

反応式

[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[C:11]([C:15](=O)[CH3:16])[CH:12]=[N:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:18].[NH2:19][OH:20].C(=O)([O-])[O-].[K+].[K+]>>[ClH:18].[C:1]1([C:7]#[C:8][C:9]2[CH:10]=[C:11]([C:15](=[N:19][OH:20])[CH3:16])[CH:12]=[N:13][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

反応物 3

HCID 11430Potassium Carbonate

HCID 443297Hydroxyamine hydrochloride

HCID 67047758HCID 67047758、化合物

生成物 1

HCID 866224851-(5-Phenylethynyl-pyridin-3-yl)-ethanone oxime hydrochloride

実験手順

Prepared in the same manner as described in EXAMPLE 6, using 1-(5-phenylethynyl-pyridin-3-yl)-ethanone, (prepared as described in EXAMPLE 166), (0.22 g, 0.97 mmol), hydroxylamine hydrochloride (0.54 g, 7.78 mmol) and potassium carbonate (0.67 g, 4.86 mmol) to give the free base of the title compound. Convert the free base to the hydrochloride salt as described in EXAMPLE 163 to give the title compound (0.112 g, 42%).

後処理

customPrepared in the same manner

出典と根拠

ORDレコード: ord-9430417098814bf9ac28402f5ce7b5c1
出典データセット: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07915424B2

反応ノート

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