Citronellal → (-)-Isopulegol

HRID 607341

反応式

HRID 607341 の反応式
[CH3:1][C:2](=[CH:4][CH2:5][CH2:6][CH:7]([CH2:9][CH:10]=[O:11])[CH3:8])[CH3:3]>[Br-].[Zn+2].[Br-].C1(C)C=CC=CC=1>[CH3:8][C@H:7]1[CH2:9][C@@H:10]([OH:11])[C@H:4]([C:2]([CH3:3])=[CH2:1])[CH2:5][CH2:6]1

参加物

4

反応物 1

HCID 7794Citronellal

生成物 1

HCID 170833(-)-Isopulegol

試薬・触媒・溶媒 2

HCID 10421208Zinc bromide触媒HCID 1140Toluene溶媒

実験手順

0.001 mmol zinc bromide is initially introduced into 70 ml toluene under an inert gas. The reaction solution is then temperature-controlled at 85° C. and 0.05 mol citronellal are metered into the reaction solution. The heterogeneous reaction mixture is then stirred at this temperature for 4 h. Thereafter, the reaction mixture is washed with 50 ml 15% strength sodium hydroxide solution and, after washing neutral, the solvent is removed from the reaction mixture under reduced pressure.

後処理

  1. customtemperature-controlled at 85° C.
  2. washThereafter, the reaction mixture is washed with 50 ml 15% strength sodium hydroxide solution
  3. washafter washing neutral
  4. customthe solvent is removed from the reaction mixture under reduced pressure

出典と根拠

ORDレコード
ord-e15a68c827eb4cd9995b5072fdc85b13
出典データセット
uspto-grants-2011_03
特許番号
US07915457B2

関連ノート

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