Citronellal → (-)-Isopulegol
反応式
[CH3:1][C:2](=[CH:4][CH2:5][CH2:6][CH:7]([CH2:9][CH:10]=[O:11])[CH3:8])[CH3:3]>[Br-].[Zn+2].[Br-].C1(C)C=CC=CC=1>[CH3:8][C@H:7]1[CH2:9][C@@H:10]([OH:11])[C@H:4]([C:2]([CH3:3])=[CH2:1])[CH2:5][CH2:6]1参加物
4
実験手順
0.001 mmol zinc bromide is initially introduced into 70 ml toluene under an inert gas. The reaction solution is then temperature-controlled at 85° C. and 0.05 mol citronellal are metered into the reaction solution. The heterogeneous reaction mixture is then stirred at this temperature for 4 h. Thereafter, the reaction mixture is washed with 50 ml 15% strength sodium hydroxide solution and, after washing neutral, the solvent is removed from the reaction mixture under reduced pressure.
後処理
- customtemperature-controlled at 85° C.
- washThereafter, the reaction mixture is washed with 50 ml 15% strength sodium hydroxide solution
- washafter washing neutral
- customthe solvent is removed from the reaction mixture under reduced pressure
出典と根拠
- ORDレコード
- ord-e15a68c827eb4cd9995b5072fdc85b13
- 出典データセット
- uspto-grants-2011_03
- 特許番号
- US07915457B2
反応ノート
読み込み中…