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3-(Methylamino)propane-1,2-diol → N-[{3-[(2,3-dihydroxypropyl)(methyl)amino]propyl}(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Methylamino)propane-1,2-diol | HCID 2734122 | — |
| 反応物 | N-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide | HCID 76585264 | — |
| 生成物 | N-[{3-[(2,3-dihydroxypropyl)(methyl)amino]propyl}(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide | HCID 76585224 | — |
反応手順
In a manner similar to that described for Example 508, N-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide and 3-methylamino-1,2-propanediol were converted to the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07915443B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-51f9e9b8266c43e494d304aa85b158cc |
| 出典メモ | uspto-grants-2011_03 |