1-Methylimidazole → HCID 67047038、化合物

HRID 607498ノート

反応式

HRID 607498 の反応式
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:12])[CH3:11])=[CH:6][CH:5]=1)=[CH2:3].CN1C=CN=C1.[N+](=[CH:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])=[N-]>C1(C)C=CC=CC=1>[C:10]([C:7]1[CH:8]=[CH:9][C:4]([C:2]2([CH3:3])[CH2:1][CH:21]2[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:5][CH:6]=1)(=[O:12])[CH3:11]

参加物

5

反応物 3

HCID 13901-MethylimidazoleHCID 12192Ethyl diazoacetateHCID 589438p-Isopropenylacetophenone

生成物 1

HCID 67047038HCID 67047038、化合物収率 22%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a stirred solution of 1-[4-(1-methylethenyl)phenyl]ethanone (711 mg, 4.44 mmol, trans) (Org. Lett., 2002, 4(1), 107-109), N-methylimidazole (1.06 ml, 13.3 mmol) and Co(TPP) (89 mg, 0.13 mmol) in toluene (10 ml) was added ethyl diazoacetate (0.65 ml, 6.21 mmol) in one portion at ambient temperature. The same procedure as described in Example 2H was performed to give the title compound (236 mg, 22%) as dark yellow oil.

出典と根拠

ORDレコード
ord-ed58b3e899f345e988a501950cd767f0
出典データセット
uspto-grants-2011_03
特許番号
US07915448B2

反応ノート

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