(4-(Cyclopentylcarbamoyl)phenyl)boronic acid → Biphenyl

HRID 608093

反応式

HRID 608093 の反応式
CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(Cl)c(C)cc21.CCN=P(N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C.O=C(NC1CCCC1)c1ccc(B(O)O)cc1>CC(C)c1cc(C(C)C)c(-c2ccccc2[PH](C(C)(C)C)(C(C)(C)C)[Pd]2([O]S(C)(=O)=O)[NH]c3ccccc3-c3cccc[c]32)c(C(C)C)c1.CS(C)=O.O>CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(-c3ccc(C(=O)NC4CCCC4)cc3)c(C)cc21

参加物

9

反応物 2

HCID 2773358(4-(Cyclopentylcarbamoyl)phenyl)boronic acidHCID 24805585tert-Butyl (R)-3-(2-acetamidopropan-2-yl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

生成物 3

HCID 7095BiphenylHCID 24805585tert-Butyl (R)-3-(2-acetamidopropan-2-yl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylateHCID 178474758HCID 178474758、化合物

試薬・触媒・溶媒 4

HCID 178439025HCID 178439025、化合物触媒HCID 679Dimethyl Sulfoxide溶媒4 回HCID 962Water溶媒HCID 33931062,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineその他

後処理

  1. additionAfter 22 hours the crude reactions were diluted with 3 x 1 uL 0.5 M AcOH in DMSO (containing PhPh as an internal standard). The reactions were mixed after each dispense operation.
  2. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis.

出典と根拠

ORDレコード
ord-aae2530bb5e040adbea7691d78bb7869
出典データセット
Cernak miniaturized Suzuki Cross-Coupling 12x10 Informer Library
元リンク
出典を表示

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