2,4-Dichloropyrimidine → Methyl 2-(2-chloropyrimidin-4-yl)-5-methylbenzoate

HRID 60935

反応式

HRID 60935 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[CH:13]=NN(C)C=2)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].CC1C=CC(B2OC(C)(C)C(C)(C)O2)=C(C=1)C(OC)=O.[Cl:38][C:39]1[N:44]=C(Cl)C=[CH:41][N:40]=1>>[Cl:38][C:39]1[N:44]=[C:12]([C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:11][C:6]=2[C:7]([O:9][CH3:10])=[O:8])[CH:13]=[CH:41][N:40]=1

参加物

4

反応物 3

HCID 775312,4-DichloropyrimidineHCID 46856403Methyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoateHCID 117727848Methyl 5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoate

生成物 1

HCID 117727617Methyl 2-(2-chloropyrimidin-4-yl)-5-methylbenzoate

実験手順

The title compound was synthesized following the same general protocol as described for methyl 5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoate in Example A1, using methyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate and 2,4-dichloropyrimidine. ESI-MS (m/z): 263 [M+1]+.

出典と根拠

ORDレコード
ord-5d81e4ba5f6343f09f530925509d1f00
出典データセット
uspto-grants-2016_09
特許番号
US09440982B2

関連ノート

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