N-benzyl-3-nitrobenzamide → 3-amino-N-benzylbenzamide

HRID 609575ノート

反応式

HRID 609575 の反応式
[C:1]1([CH2:7][NH:8][C:9](=[O:19])[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-])=O)[CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>CO.[Pd]>[C:1]1([CH2:7][NH:8][C:9](=[O:19])[C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH2:16])[CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 2

HCID 347075N-benzyl-3-nitrobenzamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 41998383-amino-N-benzylbenzamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A sample of the product of step (a), 8.8 g, was dissolved in 100 ml of methanol and hydrogenated with 0.4 g of 10% palladium on carbon and 50 PSI hydrogen. After 90 minutes, the mix was filtered and evaporated. The solid residue was slurried in ethyl ether, and filtered to provide crude N-phenylmethyl-3-aminobenzamide, mp 95-100° C, m.s. (M+H)+ =227

後処理

  1. filtrationthe mix was filtered
  2. customevaporated
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-06a9e500ffbf42d2b1e976035826e0c8
出典データセット
uspto-grants-1999_12
特許番号
US05998399

反応ノート

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