Sodium Hydroxide → 2-[4-(4-Methoxybutoxy)pyridine-2-yl]methylthio-1H-benzimidazole

HRID 609846ノート

反応式

HRID 609846 の反応式
[SH:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.Cl[CH2:12][C:13]1[CH:18]=[C:17]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][O:24][CH3:25])[CH:16]=[CH:15][N:14]=1.[OH-].[Na+]>C(O)C>[CH3:25][O:24][CH2:23][CH2:22][CH2:21][CH2:20][O:19][C:17]1[CH:16]=[CH:15][N:14]=[C:13]([CH2:12][S:1][C:2]2[NH:6][C:5]3[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=3[N:3]=2)[CH:18]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 151662232-Chloromethyl-4-(4-methoxybutoxy)pyridineHCID 178527775HCID 178527775、化合物

生成物 1

HCID 151663272-[4-(4-Methoxybutoxy)pyridine-2-yl]methylthio-1H-benzimidazole収率 70.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture comprising 2.55 g (0.017 mol) of 2-mercaptobenzimidazole, 5.09 g (0.022 mol) of 2-chloromethyl-4-(4-methoxybutoxy)pyridine, 0.84 g (0.020 mol) of 95% sodium hydroxide and 60 ml of ethanol was stirred at 40° C. for 1.5 hours. After the completion of the reaction, the reaction mixture was distilled to remove the solvent. The obtained residue was purified by silica gel column chromatography (ethyl acetate/n-hexane) to obtain 4.13 g of the title compound.

後処理

  1. customAfter the completion of the reaction
  2. distillationthe reaction mixture was distilled
  3. customto remove the solvent
  4. customThe obtained residue was purified by silica gel column chromatography (ethyl acetate/n-hexane)

出典と根拠

ORDレコード
ord-211abb6927b54b55b65a17a3e0724d12
出典データセット
uspto-grants-1999_12
特許番号
US05998445

反応ノート

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