Water → 3-(4-Fluorophenyl)-6-methylpicolinic acid
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:15]#N)=[N:10][C:11]([CH3:14])=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[OH-:17].[Na+].[OH2:19]>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:15]([OH:19])=[O:17])=[N:10][C:11]([CH3:14])=[CH:12][CH:13]=2)=[CH:4][CH:3]=1参加物
5
反応条件
- 温度
- 100 °C
実験手順
To the solution of 3-(4-fluorophenyl)-6-methylpicolinonitrile (0.555 g, 2.615 mmol) in MeOH (3 mL) was added NaOH (1.1 g, 27.5 mmol) and H2O (1.8 mL). The mixture was heated at 100° C. for 8 h. The reaction was cooled to rt and acidified to pH-5. The solvent was removed in vacuo. The crude was extracted with MeOH. The solvent was removed in vacuo and the obtained acid was dried in vacuum for next step with no further purification. ESI-MS (m/z): 233 [M+1]+.
後処理
- temperatureThe reaction was cooled to rt
- customThe solvent was removed in vacuo
- extractionThe crude was extracted with MeOH
- customThe solvent was removed in vacuo
- customthe obtained acid was dried in vacuum for next step with no further purification
出典と根拠
- ORDレコード
- ord-db06a1b42d6e4a128ca34831ff6e42a1
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09440982B2
反応ノート
読み込み中…