Aniline → 3-Nitrobenzanilide

HRID 610074

反応式

HRID 610074 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[N+:15]([C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21](Cl)=[O:22])([O-:17])=[O:16].C(=O)(O)[O-].[Na+]>ClCCl>[N+:15]([C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:22])([O-:17])=[O:16]

参加物

6

反応物 4

HCID 6115AnilineHCID 8471TriethylamineHCID 8495Benzoyl chloride, 3-nitro-HCID 516892Sodium Bicarbonate

生成物 1

HCID 3477553-Nitrobenzanilide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

To a cooled (0° C.) solution of aniline (17 g, 180 mmol) and triethylamine (27 mL, 190 mmol) in dichloromethane (100 mL) was added a solution of 3-nitrobenzoyl chloride (30 g, 160 mmol) in dichloromethane (60 mL). The mixture was stirred for 15 min at 0° C. then overnight at room temperature. It was then poured into saturated sodium bicarbonate (1 L) and stirred vigorously for 15 min. The precipitate was collected, washed with water and dried (40 g, 100%).

後処理

  1. customovernight
  2. customat room temperature
  3. stirringstirred vigorously for 15 min
  4. customThe precipitate was collected
  5. washwashed with water
  6. customdried (40 g, 100%)

出典と根拠

ORDレコード
ord-68e152fdc1f3477bba21a2bec2bf8b0b
出典データセット
uspto-grants-1999_12
特許番号
US05998463

関連ノート

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