Methanol → 3,5,6-Trifluoro-4-methylpyridin-2-amine
反応式
CO.C([NH:10][C:11]1[C:16]([F:17])=[C:15]([CH3:18])[C:14]([F:19])=[C:13]([F:20])[N:12]=1)C1C=CC=CC=1>[Pd].C(O)(=O)C>[NH2:10][C:11]1[C:16]([F:17])=[C:15]([CH3:18])[C:14]([F:19])=[C:13]([F:20])[N:12]=1参加物
5
実験手順
To 4 ml of methanol were added all amount of the crude 2-benzylamino-3,5,6-trifluoro-4-methylpyridine as described above together with 0.18 g of 10% palladium on carbon and 2 ml of acetic acid, and the mixture was hydrogenated at 50° C. for one day. The catalyst was separated by filtration, and the solvent and the like were distilled off under reduced pressure to obtain 1.35 g of the title compound as a colorless solid.
後処理
- customThe catalyst was separated by filtration
- distillationthe solvent and the like were distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-33fb23e7438f4ce4aa9d4e4ca323c6c0
- 出典データセット
- uspto-grants-1999_12
- 特許番号
- US05998436
反応ノート
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