化工社化工社 化学情報印刷レポート · 研究参考用
HRID 61025作成日：2026年10月26日
Potassium Carbonate → ((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone
https://huagongshe.com/reaction/61025
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Chloro-5-trifluoromethyl-(1,3,4)thiadiazole | HCID 13246789 | — |
| 反応物 | ((2S,3R)-2-(Aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone | HCID 89740674 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | ((2S,3R)-3-Methyl-2-(((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone | HCID 117727799 | — |
反応手順
A mixture of ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone (0.032 g, 0.1 mmol), 2-chloro-5-(trifluoromethyl)-1,3,4-thiadiazole (0.019 g, 0.1 mmol) and K2CO3 (0.018 g, 0.13 mmol) in DMF was heated at 80° C. overnight. The mixture was purified via preparative-HPLC to obtain the title compound. ESI-MS (m/z): 466 [M+1]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09440982B2 |
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| 出典データセット | uspto-grants-2016_09 |
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| ORD ID | ord-e25ffff606ea4a159a2956e4c7ca8e49 |
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| 出典メモ | uspto-grants-2016_09 |
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