Methyl iodide → Methyl 3-(benzyloxy)-5-methoxybenzoate

反応式

[OH:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([OH:12])[CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.I[CH3:22]>>[CH2:13]([O:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([O:12][CH3:22])[CH:11]=1)[C:5]([O:7][CH3:8])=[O:6])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

反応物 3

HCID 6328Methyl iodide

HCID 7498Benzyl Bromide

HCID 75076Methyl 3,5-Dihydroxybenzoate

生成物 1

HCID 12658782Methyl 3-(benzyloxy)-5-methoxybenzoate

実験手順

Following the procedure of Example 80(a) except substituting methyl 3-hydroxy-5-methoxybenzoate for methyl 3,5-dihydroxybenzoate and benzyl bromide for iodomethane, the title compound was prepared as a tan oil (1.2 g, 4.4 mmol). 1H NMR (400 MHz, CDCl3) δ 7.45-7.31 (m, 6H), 7.24 (s, 1H), 6.76 (m, 1H), 5.09 (s, 2H), 3.95 (s, 3H), 3.84 (s, 3H).

出典と根拠

ORDレコード: ord-965a48f7e2af4a1ea1cfd99ef4fd8261
出典データセット: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05998470

反応ノート

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