3-Phenylsalicylic acid → 2-(2,4-Dimethyl-3-pentyloxy)carbonyl-6-phenylphenol

HRID 610459

反応式

HRID 610459 の反応式
CS([O:5][CH:6]([CH:10]([CH3:12])[CH3:11])[CH:7]([CH3:9])[CH3:8])(=O)=O.[C:13]1([C:19]2[CH:27]=[CH:26][CH:25]=[C:21]([C:22](O)=[O:23])[C:20]=2[OH:28])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O>[CH3:8][CH:7]([CH:6]([O:5][C:22]([C:21]1[CH:25]=[CH:26][CH:27]=[C:19]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:20]=1[OH:28])=[O:23])[CH:10]([CH3:12])[CH3:11])[CH3:9]

参加物

5

反応物 3

HCID 93483-Phenylsalicylic acidHCID 10340Sodium CarbonateHCID 54447467(2,4-Dimethyl-3-pentyl) methanesulfonate

生成物 1

HCID 110560652-(2,4-Dimethyl-3-pentyloxy)carbonyl-6-phenylphenol収率 64%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

In a four-neck flask having an inner volume of 100 ml, 4.86 g (25 m.mols) of (2,4-dimethyl-3-pentyl) methanesulfonate, 5.36 g (25 m.mols) of 3-phenylsalicylic acid, 2.65 g (25 m.mols) of sodium carbonate, and 50 ml of dimethyl formamide were placed and left reacting at 90° C. for three hours. After the reaction, the reaction mass was thrown into 100 ml of ice water and extracted twice with 150 ml of ethyl acetate. The organic layer obtained consequently was washed twice with 50 ml of water. Then, by distilling the organic layer thereby expelling the solvent by evaporation, 5.00 g (16 m.mols) of 2-(2,4-dimethyl-3-pentyloxy)carbonyl-6-phenylphenol was obtained as the product aimed at.

後処理

  1. customIn a four-neck flask having
  2. waitleft
  3. customAfter the reaction
  4. extractionextracted twice with 150 ml of ethyl acetate
  5. customThe organic layer obtained consequently
  6. washwas washed twice with 50 ml of water
  7. distillationThen, by distilling the organic layer
  8. customby evaporation

出典と根拠

ORDレコード
ord-40d1a19b81ae45b9b295034e5f43b00b
出典データセット
uspto-grants-1999_12
特許番号
US05998609

関連ノート

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