Tetrafluorophthalonitrile → 3,5,6-Trifluoro-4-(2-(2,4-dimethyl-3-pentyloxy)carbonyl-6-phenylphenoxy)phthalonitrile

HRID 610460

反応式

HRID 610460 の反応式
[F:1][C:2]1[C:9]([F:10])=[C:8](F)[C:7]([F:12])=[C:4]([C:5]#[N:6])[C:3]=1[C:13]#[N:14].[CH3:15][CH:16]([CH:18]([O:22][C:23]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:26]=1[OH:37])=[O:24])[CH:19]([CH3:21])[CH3:20])[CH3:17].[F-].[K+]>C(#N)C>[F:12][C:7]1[C:8]([O:37][C:26]2[C:27]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[CH:28][CH:29]=[CH:30][C:25]=2[C:23]([O:22][CH:18]([CH:19]([CH3:21])[CH3:20])[CH:16]([CH3:15])[CH3:17])=[O:24])=[C:9]([F:10])[C:2]([F:1])=[C:3]([C:13]#[N:14])[C:4]=1[C:5]#[N:6]

参加物

5

反応物 3

HCID 74600TetrafluorophthalonitrileHCID 522689Potassium FluorideHCID 110560652-(2,4-Dimethyl-3-pentyloxy)carbonyl-6-phenylphenol

生成物 1

HCID 118270963,5,6-Trifluoro-4-(2-(2,4-dimethyl-3-pentyloxy)carbonyl-6-phenylphenoxy)phthalonitrile収率 93.4%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

In a four-neck flask having an inner volume of 100 ml, 3.00 g (15 m.mols) of 3,4,5,6-tetrafluorophthalonitrile, 4.69 g (15 m.mols) of 2-(2,4-dimethyl-3-pentyloxy)carbonyl-6-phenylphenol, 2.62 g (45 m.mols) of potassium fluoride, and 50 ml of acetonitrile were placed and left reacting under reflux for six hours. After the reaction, the reaction mass was filtered and then distilled to expel the solvent by evaporation and obtain 6.90 g (14 m.mols) of 3,5,6-trifluoro-4-(2-(2,4-dimethyl-3-pentyloxy)carbonyl-6-phenylphenoxy)phthalonitrile as the product aimed at.

後処理

  1. customIn a four-neck flask having
  2. waitleft
  3. temperatureunder reflux for six hours
  4. customAfter the reaction
  5. filtrationthe reaction mass was filtered
  6. distillationdistilled
  7. customby evaporation

出典と根拠

ORDレコード
ord-4b86f58a821b4d5791afa694cdbc2781
出典データセット
uspto-grants-1999_12
特許番号
US05998609

関連ノート

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