Methanol → Methyl 2-amino-4-methylbenzoate

HRID 610761

反応式

HRID 610761 の反応式
[NH2:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH3:17]O>>[NH2:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH3:17])=[O:5]

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 753164-Methylanthranilic acid

生成物 1

HCID 11205965Methyl 2-amino-4-methylbenzoate

実験手順

A mixture of 2-amino-4-methylbenzoic acid (15.0 g) and concentrated sulphuric acid (20 ml) was heated under reflux with methanol for 18 hours. After removal of the solvent the residue was dissolved in dichloromethane, basified with sodium carbonate solution and the organic phase was washed with water, dried (anhydrous magnesium sulphate) and the solvent evaporated to give methyl 2-amino-4-methylbenzoate, m.p. 41-43° C.

後処理

  1. temperaturewas heated
  2. customAfter removal of the solvent the residue
  3. dissolutionwas dissolved in dichloromethane
  4. washthe organic phase was washed with water
  5. dry with materialdried (anhydrous magnesium sulphate)
  6. customthe solvent evaporated

出典と根拠

ORDレコード
ord-fb508853e26b4053b9f31d5c61b56625
出典データセット
uspto-grants-1999_12
特許番号
US05998653

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