HCID 10659336、化合物 → N-[3-(acetyl-methyl-amino)-5-amino-phenyl]-N-methyl-acetamide

反応式

[C:1]([N:4]([CH3:19])[C:5]1[CH:6]=[C:7]([N:14]([CH3:18])[C:15](=[O:17])[CH3:16])[CH:8]=[C:9]([N+:11]([O-])=O)[CH:10]=1)(=[O:3])[CH3:2].[H][H]>C(O)C.[Pd]>[C:1]([N:4]([CH3:19])[C:5]1[CH:6]=[C:7]([N:14]([CH3:18])[C:15](=[O:17])[CH3:16])[CH:8]=[C:9]([NH2:11])[CH:10]=1)(=[O:3])[CH3:2]

参加物

実験手順

0.19 g (0.00072 mol) of N-[3-(acetyl-methyl-amino)-5-nitro-phenyl]-N-methyl-acetamide was dissolved in 15 ml of ethanol, treated with 0.019 g of Pd/C (10%) and hydrogenated with hydrogen gas at room temperature for 2 hours. The catalyst was filtered off, the solvent was distilled off and the residue was chromatographed on silica gel with ethyl acetate. There was obtained 0.16 g (94%) of N-[3-(acetyl-methyl-amino)-5-amino-phenyl]-N-methyl-acetamide as white crystals; m.p.: 179-181° C.