Formaldehyde → HCID 19600068、化合物
反応式
C(O[C:6]([N:8]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:9][CH2:10][CH2:11][C:12]1[CH:16]=[CH:15][O:14][CH:13]=1)=O)(C)(C)C.C=O>C(O)(=O)C>[C:23]1([CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][N:8]2[CH2:9][CH2:10][CH2:11][C:12]3[CH:16]=[CH:15][O:14][C:13]=3[CH2:6]2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
To a solution of the above crude N-[3-(3-furyl)propyl]-6-phenylhexylamine in 100 ml of acetic acid, 0.74 g (9.1 mmol) of 37% aqueous formaldehyde was added, followed by stirring at 100° C. for 1 hour. After the solvent was distilled off under reduced pressure, the residual solution was alkalified with aqueous sodium hydroxide and extracted with dichloromethane 3 times. The combined organic layer was dried over anhydrous magnesium sulfate; the solvent was distilled off under reduced pressure. The resulting crude product was purified by silica gel column chromatography (hexane/ethyl acetate=9/1 to 3/1) to yield the desired product.