Ammonium Chloride → 5-(4-Aminophenyl)-4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidine

HRID 611532ノート

反応式

HRID 611532 の反応式
[Cl:1][C:2]1[C:3]2[C:10]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=3)=[CH:9][N:8]([CH:20]([CH3:22])[CH3:21])[C:4]=2[N:5]=[CH:6][N:7]=1.[Cl-].[NH4+]>[Fe].O>[NH2:17][C:14]1[CH:15]=[CH:16][C:11]([C:10]2[C:3]3[C:2]([Cl:1])=[N:7][CH:6]=[N:5][C:4]=3[N:8]([CH:20]([CH3:22])[CH3:21])[CH:9]=2)=[CH:12][CH:13]=1

参加物

5

反応物 2

HCID 25517Ammonium ChlorideHCID 195974814-Chloro-7-isopropyl-5-(4-nitrophenyl)pyrrolo[2,3-d]pyrimidine

生成物 1

HCID 195974875-(4-Aminophenyl)-4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidine

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 962Water溶媒

実験手順

A mixture of 4-chloro-7-isopropyl-5-(4-nitrophenyl)pyrrolo[2,3-d]pyrimidine (1.0 g), iron powder (1.76 g), ammonium chloride (86 mg), water (8 ml) and industrial methylated spirit (40 ml) was boiled under reflux for one hour. The mixture was filtered and the solvent evaporated. The residue was taken up in ethyl acetate and washed with water. The ethyl acetate extract was dried, filtered and evaporated to give 5-(4-aminophenyl)-4-chloro-7-isopropylpyrrolo[2,3-d]pyrimidine.

後処理

  1. temperatureunder reflux for one hour
  2. filtrationThe mixture was filtered
  3. customthe solvent evaporated
  4. washwashed with water
  5. extractionThe ethyl acetate extract
  6. customwas dried
  7. filtrationfiltered
  8. customevaporated

出典と根拠

ORDレコード
ord-4836753ec72e49499603987c56851b6e
出典データセット
uspto-grants-1999_12
特許番号
US06001839

反応ノート

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