2-Methoxyaniline → 4-Bromo-2-methoxyaniline

反応式

[CH3:1][O:2][C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5].[Br:10]C1C(=O)C(Br)=CC(Br)(Br)C=1>>[Br:10][C:8]1[CH:7]=[CH:6][C:4]([NH2:5])=[C:3]([O:2][CH3:1])[CH:9]=1

参加物

反応物 2

HCID 70002-Methoxyaniline

HCID 884332,4,4,6-Tetrabromocyclohexa-2,5-dienone

生成物 1

HCID 4592574-Bromo-2-methoxyaniline

実験手順

2-Methoxyaniline was brominated with 2,4,4,6-tetrabromo-2,5-cyclohexadien-1-one to give 4-bromo-2-methoxyaniline which was reacted with di-tert-butyldicarbonate in tetrahydrofuran to protect the amine group. The product was treated with butyllithium at -78° C. and then with trimethyltin chloride to give 4-tert-butoxycarbonylamino-3-methoxyphenyl trimethyl stannane.

出典と根拠

ORDレコード: ord-81be778add174383838e4f6b692fb180
出典データセット: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06001839

反応ノート

読み込み中…

参加物