HCID 178470564、化合物 → HCID 178433209、化合物
反応式
Cl.[NH:2]([C:6]1[S:7][C:8]([C:12]([O:14]CC)=[O:13])=[C:9]([CH3:11])[N:10]=1)[C:3]([NH2:5])=[NH:4]>C(O)C.[OH-].[Na+]>[NH:2]([C:6]1[S:7][C:8]([C:12]([OH:14])=[O:13])=[C:9]([CH3:11])[N:10]=1)[C:3]([NH2:5])=[NH:4]参加物
4
実験手順
2.65 g of ethyl 2-guanidino-4-methyl-thiazole-5-carboxylate hydrochloride (prepared according to Example 3) are heated to 75° C. for 7 hrs. in 70 ml of ethanol and 11 ml of 2N NaOH. The reaction mixture is evaporated to dryness in a vacuum. The residue is taken up in 40 ml of ethanol, the solution is filtered clear and the product is precipitated with 2 ml of acetic acid. There are obtained 1.82 g of 2-guanidino-4-methyl-thiazole-5-carboxylic acid of m.p. 1 96° C.
後処理
- customThe reaction mixture is evaporated to dryness in a vacuum
- filtrationthe solution is filtered clear
- customthe product is precipitated with 2 ml of acetic acid
出典と根拠
- ORDレコード
- ord-40d500609e744d1e9540600345e1b8a7
- 出典データセット
- uspto-grants-1999_12
- 特許番号
- US06001855
反応ノート
読み込み中…