Triethylamine → HCID 18551366、化合物

HRID 611701ノート

反応式

HRID 611701 の反応式
C(N(CC)CC)C.[N+:8]([C:11]1[C:12]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:13]([CH:17]=[CH:18][CH:19]=1)[C:14]([OH:16])=O)([O-:10])=[O:9].ClC(OCC(C)C)=O.[F:36][C:37]1[CH:42]=[CH:41][C:40]([CH:43]([NH2:45])[CH3:44])=[CH:39][CH:38]=1>ClCCl>[N+:8]([C:11]1[C:12]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:13]([CH:17]=[CH:18][CH:19]=1)[C:14]([NH:45][CH:43]([C:40]1[CH:41]=[CH:42][C:37]([F:36])=[CH:38][CH:39]=1)[CH3:44])=[O:16])([O-:10])=[O:9]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 62365Isobutyl chloroformateHCID 1230631-(4-Fluorophenyl)ethylamineHCID 222726693-Nitro-2-(phenylmethoxy)benzoic acid

生成物 1

HCID 18551366HCID 18551366、化合物収率 57.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

2.4 g (0.011 mol) of triethylamine are added at -10° C. to a solution of 3 g (0.011 mol) of 3-nitro-2-benzyloxybenzoic acid in 40 ml of dichloromethane. After the mixture has been stirred for 5 minutes, 2.8 g (0.011 mol) of isobutyl chloroformate are added dropwise at -10° C., and the mixture is stirred for a further minutes. A solution of 1.53 g (0.011 mol) of 1-(4-fluorophenyl)-ethylamine in 10 ml of dichloromethane is added at -10° C., and stirring is continued for 12 hours without further cooling. The mixture is treated with sodium halogen carbonate solution, and the organic phase is separated off, washed with water and dried over sodium sulphate. After the solvent has been distilled off, 2.5 g (56% of theory) of 3-nitro-2-benzyloxy-N-[1-(4-fluorophenyl)-ethyl)-benzamide are obtained as an oil.

後処理

  1. stirringthe mixture is stirred for a further minutes
  2. stirringstirring
  3. waitis continued for 12 hours without further cooling
  4. customthe organic phase is separated off
  5. washwashed with water
  6. dry with materialdried over sodium sulphate
  7. distillationAfter the solvent has been distilled off

出典と根拠

ORDレコード
ord-c040c8bfd7344740812adebaa2db7db3
出典データセット
uspto-grants-1999_12
特許番号
US06001879

反応ノート

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