Sodium Hydroxide → 2-Oxo-1-phenylpiperidine-3-carboxylic acid
反応式
[C:1]([CH:6]1[CH2:11][CH2:10][CH2:9][N:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:7]1=[O:18])([O:3]CC)=[O:2].[OH-].[Na+]>CO>[C:1]([CH:6]1[CH2:11][CH2:10][CH2:9][N:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:7]1=[O:18])([OH:3])=[O:2]参加物
4
実験手順
The product from Step C (0.551 g, 2.56 mmol) was dissolved in methanol (3 mL) and 5% aqueous sodium hydroxide added (3 mL). After 11 h, methanol was removed in vacuo, and the residue partitioned between ethyl acetate and 10% aqueous HCl. The organic layer was washed with saturated brine, and dried over MgSO4. The title compound was obtained as a white solid.
後処理
- custommethanol was removed in vacuo
- customthe residue partitioned between ethyl acetate and 10% aqueous HCl
- washThe organic layer was washed with saturated brine
- dry with materialdried over MgSO4
出典と根拠
- ORDレコード
- ord-d61641d03e614d8fb3cd49991fce9e85
- 出典データセット
- uspto-grants-1999_12
- 特許番号
- US06001835
反応ノート
読み込み中…