Methane → 4-(3-Dimethylaminophenylamino)-6-nitroquinoline-3-carbonitrile

HRID 612268

反応式

HRID 612268 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:15]#[N:16].Cl.Cl.[CH3:19][N:20]([CH3:28])[C:21]1[CH:22]=[C:23]([CH:25]=[CH:26][CH:27]=1)[NH2:24].C(N(CC)CC)C.C>CCOC(C)=O>[CH3:19][N:20]([CH3:28])[C:21]1[CH:22]=[C:23]([NH:24][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=3)[N:5]=[CH:4][C:3]=2[C:15]#[N:16])[CH:25]=[CH:26][CH:27]=1

参加物

6

反応物 4

HCID 297MethaneHCID 8471TriethylamineHCID 771241,3-Benzenediamine, N1,N1-dimethyl-, hydrochloride (1:2)HCID 110856904-Chloro-6-nitroquinoline-3-carbonitrile

生成物 1

HCID 224666434-(3-Dimethylaminophenylamino)-6-nitroquinoline-3-carbonitrile

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Prepared from 5.00 g of 4-chloro-6-nitroquinoline-3-carbonitrile, 5.38 g of 3-dimethylaminoaniline dihydrochloride and 5.17 g of triethylamine in the same manner as Example 377. The crude product was taken up in EtOAc, treated with Darco, filtered through Celite, evaporated and dried in vacuo (50° C.). The yield of 4-(3-dimethylaminophenylamino)-6-nitroquinoline-3-carbonitrile was 5.62 g as brick red crystals: mass spectrum (electrospray, m/e): M+H 334.2.

後処理

  1. filtrationfiltered through Celite
  2. customevaporated
  3. customdried in vacuo (50° C.)

出典と根拠

ORDレコード
ord-6cf226f92135494bbfee969ccc94b8b4
出典データセット
uspto-grants-1999_12
特許番号
US06002008

関連ノート

読み込み中…