2-Chloro-5-(trifluoromethyl)pyrimidine → (S)-(4,4-Difluoro-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone

HRID 61246

反応式

HRID 61246 の反応式
[F:1][C:2]1([F:20])[CH2:7][CH2:6][NH:5][CH:4]([CH2:8][N:9]2[C:17](=O)C3C(=CC=CC=3)C2=O)[CH2:3]1.[CH3:21][C:22]1[CH:23]=[CH:24][C:25]([C:31]2[N:36]=[CH:35][CH:34]=[CH:33][N:32]=2)=[C:26]([CH:30]=1)[C:27]([OH:29])=O.ClC1[N:43]=[CH:42][C:41]([C:44]([F:47])([F:46])[F:45])=[CH:40][N:39]=1>>[F:20][C:2]1([F:1])[CH2:7][CH2:6][N:5]([C:27]([C:26]2[CH:30]=[C:22]([CH3:21])[CH:23]=[CH:24][C:25]=2[C:31]2[N:36]=[CH:35][CH:34]=[CH:33][N:32]=2)=[O:29])[C@H:4]([CH2:8][NH:9][C:17]2[N:43]=[CH:42][C:41]([C:44]([F:47])([F:46])[F:45])=[CH:40][N:39]=2)[CH2:3]1

参加物

4

反応物 3

HCID 133170192-Chloro-5-(trifluoromethyl)pyrimidineHCID 445172645-Methyl-2-(pyrimidin-2-yl)benzoic acidHCID 1177280172-((4,4-Difluoropiperidin-2-yl)methyl)isoindoline-1,3-dione

生成物 1

HCID 117727662(S)-(4,4-Difluoro-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone

実験手順

The title compound was prepared following the same general protocol as described for Example A210 using 2-((4,4-difluoropiperidin-2-yl)methyl)isoindoline-1,3-dione and 5-methyl-2-(pyrimidin-2-yl)benzoic acid and Example A45 using 2-chloro-5-(trifluoromethyl)pyrimidine. ESI-MS (m/z): 493 (M+H).

出典と根拠

ORDレコード
ord-911f1feac7ab449b9ad60381a434343f
出典データセット
uspto-grants-2016_09
特許番号
US09440982B2

関連ノート

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