Water → Benzenamine, N-ethyl-N-2-propynyl-

HRID 612742ノート

反応式

HRID 612742 の反応式
[CH2:1]([NH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:2].[C:10](=O)([O-])[O-].[Na+].[Na+].O.CCO[CH2:20][CH3:21]>>[CH2:1]([N:3]([CH2:10][C:20]#[CH:21])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:2]

参加物

5

反応物 4

HCID 962WaterHCID 3283Diethyl EtherHCID 7670N-EthylanilineHCID 10340Sodium Carbonate

生成物 1

HCID 3683082Benzenamine, N-ethyl-N-2-propynyl-収率 56%

実験手順

The procedure follows that of (Reppe and Mitarbeiter, Annalen der Chemie, 596:38-75 (1955)). Ethylaniline (37.1 g, 0.300 Moles) and Benzenesunfonylchloride (60.7 g, 0.300 Moles); are combined in a 500 mL Erlenmeyer flask. To this is added 125 mL of 13% Sodium Carbonate and 100 mL of water and the mixture stirred for 40 hours. The mixture was extracted with ether, dried and 97 mL Acetic anhydride added, the ether evaporated, thinned with benzene and finally extracted with 3:1 Hydrochloric acid. The acidic solution was back extracted with about 30 mL of benzene before being neutralized with Sodium Carbonate, let settle overnight and finally steam distilled. The distillate was extracted with ether and the ether evaporated to 26.8 g (56% yield) of pale yellow liquid IR (neat) 3291, 3062, 3027, 2972, 2931, 2113, 1600, 1505, 1457, 1377, 1348, 1275, 1244, 1185, 1127, 1039, 1009, 750, 692, 651 cm-1 ; 1H NMR (CDCl3) δ1.27 (t, J=7.3) 2.23 (t, J=2.5, 1), 3.49 (q, J=7.2), 4.06 (d, J=2.5), 6.89 (m, 3), 7.29 (m, 2); 13C NMR (CDCl3)2 δ12.9 (--CH3), 40.1 (N--CH2 --), 46.0 (N--CH2 --), 72.1 (yneC-), 80.8 (yneC), 114.4 (arom), 118.2 (arom), 129.6 (arom), 148.3 (arom).

後処理

  1. extractionThe mixture was extracted with ether
  2. customdried
  3. addition97 mL Acetic anhydride added
  4. customthe ether evaporated
  5. extractionfinally extracted with 3:1 Hydrochloric acid
  6. extractionThe acidic solution was back extracted with about 30 mL of benzene
  7. waitlet settle overnight
  8. distillationfinally steam distilled
  9. extractionThe distillate was extracted with ether

出典と根拠

ORDレコード
ord-3c0cde8d38d14ea59fb5df15732020f4
出典データセット
uspto-grants-1999_12
特許番号
US06005058

反応ノート

読み込み中…