Thionyl Chloride → 1-(2-(4-(Chloromethyl)phenoxy)ethyl)piperidine hydrochloride
反応式
[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:17]=[CH:16][C:13]([CH2:14]O)=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:20])=O>C(Cl)CCl>[ClH:20].[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:17]=[CH:16][C:13]([CH2:14][Cl:20])=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
4
実験手順
The solution of 4-(2-piperidinylethoxy)benzyl alcohol in ethylene dichloride can be combined with thionyl chloride and heated until the reaction is complete. Upon cooling, the mixture can be concentrated, followed by addition of 1,2-dimethoxyethane and additional concentration. The precipitate can be collected and dried to yield intermediate 4-(2-piperidinylethoxy)benzylchloride hydrochloride, as shown in Scheme IX. ##STR36##
後処理
- temperatureheated until the reaction
- temperatureUpon cooling
- concentrationthe mixture can be concentrated
- additionfollowed by addition of 1,2-dimethoxyethane and additional concentration
- customThe precipitate can be collected
- customdried
出典と根拠
- ORDレコード
- ord-ab53483a79d240f7a45300f49185e261
- 出典データセット
- uspto-grants-1999_12
- 特許番号
- US06005102
反応ノート
読み込み中…