Thionyl Chloride → 3-Pyridin-3-ylpropanoyl chloride
反応式
S(Cl)([Cl:3])=O.[N:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][C:13]([OH:15])=O)[CH:6]=1>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.ClCCCl>[N:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][CH2:12][C:13]([Cl:3])=[O:15])[CH:6]=1参加物
5
実験手順
Add thionyl chloride (0.05 mL, 0.53 mmol) to a stirred suspension of 3-(3-pyridyl)propionic acid (80.2 mg, 0.53 mmol) and benzyltriethylammonium chloride (1 mg, 0.004 mmol) in 1,2-dichloroethane (20 mL) and heat to reflux for 2.5 hours. Cool the reaction mixture to room temperature and concentrate in vacuo. Azeotrope the residue with CCl4 and place under vacuum. Use the resulting acid chloride without further purification.
後処理
- temperatureheat
- temperatureto reflux for 2.5 hours
- concentrationconcentrate in vacuo
- customwithout further purification
出典と根拠
- ORDレコード
- ord-da6f477ca9344f2ab17f08116fd10489
- 出典データセット
- uspto-grants-1999_12
- 特許番号
- US06008196
反応ノート
読み込み中…