Acetic Acid → 3,4-Dimethyl-2-methylenevaleraldehyde

HRID 61326ノート

反応式

HRID 61326 の反応式
[CH2:1](NCCCC)CCC.C(O)(=O)C.C=O.[CH3:16][CH:17]([CH:21]([CH3:23])[CH3:22])[CH2:18][CH:19]=[O:20]>C1(C)C=CC=CC=1>[CH3:16][CH:17]([CH:21]([CH3:23])[CH3:22])[C:18](=[CH2:1])[CH:19]=[O:20]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 712FormaldehydeHCID 8148DibutylamineHCID 868553,4-Dimethylpentanal

生成物 1

HCID 30204233,4-Dimethyl-2-methylenevaleraldehyde

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
70 °C

実験手順

Dibutylamine (34 g), acetic acid (15.78 g), and formaldehyde (230 g) were charged to a reaction flask and heated to 70° C. 3,4-Dimethyl-pentanal (500 g) was fed over 2 hours and aged for another hour. The reaction mixture was cooled down and toluene (200 mL) was added. The reaction mixture was sequentially washed with water (2 L), sodium carbonate solution (1 L), and brine (1 L) to provide the crude product 3,4-dimethyl-2-methylene-pentanal.

後処理

  1. waitaged for another hour
  2. temperatureThe reaction mixture was cooled down
  3. washThe reaction mixture was sequentially washed with water (2 L), sodium carbonate solution (1 L), and brine (1 L)

出典と根拠

ORDレコード
ord-0e1cd97cb31d443f8b2e6efc5a30b738
出典データセット
uspto-grants-2016_09
特許番号
US09441185B2

反応ノート

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