Sodium borohydride → [1-(1,2-Dimethyl-propyl)-4-methyl-cyclohex-3-enyl]-methanol

HRID 61328

反応式

HRID 61328 の反応式
[CH3:1][CH:2]([C:6]1([CH:13]=[O:14])[CH2:11][CH2:10][C:9]([CH3:12])=[CH:8][CH2:7]1)[CH:3]([CH3:5])[CH3:4].[BH4-].[Na+]>CO>[CH3:1][CH:2]([C:6]1([CH2:13][OH:14])[CH2:11][CH2:10][C:9]([CH3:12])=[CH:8][CH2:7]1)[CH:3]([CH3:4])[CH3:5]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 897051761-(1,2-Dimethyl-propyl)-4-methyl-cyclohex-3-enecarbaldehyde

生成物 1

HCID 89705124[1-(1,2-Dimethyl-propyl)-4-methyl-cyclohex-3-enyl]-methanol収率 87.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1-(1,2-Dimethyl-propyl)-4-methyl-cyclohex-3-enecarbaldehyde (415 g) and methanol (300 mL) were charged into a reaction flask. Sodium borohydride (15 g) was added slowly and the temperature was kept at 35° C. with an ice bath. The reaction mixture was aged for 2 hours and quenched onto HCl (42 g) and ice and extracted with toluene. The reaction mixture was washed until neutral. The rushed over material provided the recovery of [1-(1,2-dimethyl-propyl)-4-methyl-cyclohex-3-enyl]methanol (366 g).

後処理

  1. customthe temperature was kept at 35° C. with an ice bath
  2. customquenched onto HCl (42 g) and ice
  3. extractionextracted with toluene
  4. washThe reaction mixture was washed until neutral

出典と根拠

ORDレコード
ord-71b3a8faa9a24e578b96d0a231b93669
出典データセット
uspto-grants-2016_09
特許番号
US09441185B2

関連ノート

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