Toluene → 2-Isopentylcyclopent-2-en-1-one
反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[C:8]1([CH3:18])[CH:13]=[CH:12][C:11](S(O)(=O)=O)=[CH:10][CH:9]=1.[C:19]1(C)C=CC=CC=1>>[CH3:19][CH:8]([CH3:18])[CH2:13][CH2:12][C:11]1[C:5](=[O:7])[CH2:6][CH2:9][CH:10]=1参加物
4
反応条件
- 温度
- 125 °C
実験手順
2-(3-Methyl-butyllidene)-cyclopentanone (1.093 Kg, 7.19 mol, obtained as detailed above), acetic anhydride (300 mL, 3.17 mol), p-toluenesulfonic acid (PTSA, 10 g), and toluene (500 mL) were charged into a flask and heated to 120-130° C. When gas chromatography analysis indicated the completion of the reaction, the reaction mixture was cooled to room temperature and quenched with Na2CO3 solution (100 mL). The resulting mixture was washed twice with brine (1 L). A rushover process provided the crude product 2-(3-methyl-butyl)-cyclopent-2-enone.
後処理
- customthe completion of the reaction
- temperaturethe reaction mixture was cooled to room temperature
- customquenched with Na2CO3 solution (100 mL)
- washThe resulting mixture was washed twice with brine (1 L)
出典と根拠
- ORDレコード
- ord-f38a1f5c245a4e0ebbe5d8bd9cdd9f36
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09441185B2
反応ノート
読み込み中…