Methanol → HCID 136404630、化合物

HRID 613348ノート

反応式

HRID 613348 の反応式
[BH4-].[Na+].C(Cl)Cl.CO.[CH:8]([C:10]1[CH:14]=[C:13]2[C:15]([C:73]3[CH:78]=[CH:77][CH:76]=[CH:75][C:74]=3[NH:79][C:80](=[O:85])[C:81]([CH3:84])([CH3:83])[CH3:82])=[C:16]3[N:20]=[C:19]([C:21]([C:60]4[CH:65]=[CH:64][CH:63]=[CH:62][C:61]=4[NH:66][C:67](=[O:72])[C:68]([CH3:71])([CH3:70])[CH3:69])=[C:22]4[NH:26][C:25](=[C:27]([C:47]5[CH:52]=[CH:51][CH:50]=[CH:49][C:48]=5[NH:53][C:54](=[O:59])[C:55]([CH3:58])([CH3:57])[CH3:56])[C:28]5[CH:29]=[CH:30][C:31](=[C:33]([C:34]6[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=6[NH:40][C:41](=[O:46])[C:42]([CH3:45])([CH3:44])[CH3:43])[C:11]=1[NH:12]2)[N:32]=5)[CH:24]=[CH:23]4)[CH:18]=[CH:17]3)=[O:9]>O>[OH:9][CH2:8][C:10]1[CH:14]=[C:13]2[C:15]([C:73]3[CH:78]=[CH:77][CH:76]=[CH:75][C:74]=3[NH:79][C:80](=[O:85])[C:81]([CH3:84])([CH3:83])[CH3:82])=[C:16]3[N:20]=[C:19]([C:21]([C:60]4[CH:65]=[CH:64][CH:63]=[CH:62][C:61]=4[NH:66][C:67](=[O:72])[C:68]([CH3:69])([CH3:70])[CH3:71])=[C:22]4[NH:26][C:25](=[C:27]([C:47]5[CH:52]=[CH:51][CH:50]=[CH:49][C:48]=5[NH:53][C:54](=[O:59])[C:55]([CH3:56])([CH3:57])[CH3:58])[C:28]5[CH:29]=[CH:30][C:31](=[C:33]([C:34]6[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=6[NH:40][C:41](=[O:46])[C:42]([CH3:43])([CH3:44])[CH3:45])[C:11]=1[NH:12]2)[N:32]=5)[CH:24]=[CH:23]4)[CH:18]=[CH:17]3

参加物

6

反応物 4

HCID 887MethanolHCID 6344DichloromethaneHCID 4311764Sodium borohydrideHCID 16167393HCID 16167393、化合物

生成物 1

HCID 136404630HCID 136404630、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

NaBH4 (41.5 mg, 1.1 mmol) was added to a solution of CH2Cl2 --MeOH (1/3 v/v) (8 ml) containing 2-formyl-5,10,15,20-tetrakis(o-pivalamidophenyl)porphyrin (0.11 g, 0.11 mmol) under argon stirred for 15 min. After adding water to the solution, the mixture was extracted by CHCl3 and washed with water. After drying (Na2SO4), the organic layer was chromatographed on a silica gel flash column using CHCl3 --MeOH (10/1 v/v) as the eluent. The residue was dried at room temperature in vacuo to give a purple product, (2-hydroxymethyl-5,10,15,20-tetrakis(o-pivalamidophenyl)porphyrin, 0.11 g, 94%).

後処理

  1. extractionthe mixture was extracted by CHCl3
  2. washwashed with water
  3. dry with materialAfter drying (Na2SO4)
  4. customthe organic layer was chromatographed on a silica gel flash column
  5. customThe residue was dried at room temperature in vacuo

出典と根拠

ORDレコード
ord-f438c2ec0f2d427da719100d28780c8b
出典データセット
uspto-grants-1999_12
特許番号
US06008198

反応ノート

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