2-Heptanol → Cyclopropanecarboxylic acid 1-methyl-hexyl ester
反応式
[CH3:1][CH:2]([OH:8])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH:9]1([C:12](O)=[O:13])[CH2:11][CH2:10]1>C1(C)C=CC(S(O)(=O)=O)=CC=1.C1(C)C=CC=CC=1>[CH3:1][CH:2]([O:8][C:12]([CH:9]1[CH2:11][CH2:10]1)=[O:13])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]参加物
5
実験手順
2-Heptanol (200 g, 1.72 mol) and cyclopropanecarboxylic acid (163 g, 1.90 mol) were added into toluene (500 mL), followed by p-toluenesulfonic acid (3.2 g, 0.0172 mol). The reaction mixture was heated to reflux for 6 hours, cooled to room temperature, and quenched with aqueous sodium bicarbonate (1 L). The reaction mixture was then washed with brine (0.5 L) and dried over sodium sulfate (50 g). The solvent was removed and the reaction mixture was distilled to provide the product cyclopropanecarboxylic acid 1-methyl-hexyl ester (253 g).
後処理
- temperatureThe reaction mixture was heated
- temperatureto reflux for 6 hours
- customquenched with aqueous sodium bicarbonate (1 L)
- washThe reaction mixture was then washed with brine (0.5 L)
- dry with materialdried over sodium sulfate (50 g)
- customThe solvent was removed
- distillationthe reaction mixture was distilled
出典と根拠
- ORDレコード
- ord-59cafe26ff9e483eae52495a7a1c2ddb
- 出典データセット
- uspto-grants-2016_09
- 特許番号
- US09441185B2
反応ノート
読み込み中…