Hydroquinone → 4-(Allyloxy)phenol
反応式
[C:1]1([CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1)[OH:2].C(=O)([O-])[O-].[K+].[K+].[CH2:15](Br)[CH:16]=[CH2:17]>CN(C=O)C>[CH2:17]([O:2][C:1]1[CH:8]=[CH:7][C:5]([OH:6])=[CH:4][CH:3]=1)[CH:16]=[CH2:15]参加物
5
実験手順
A solution of hydroquinone (33.00 g, 0.30 mol) and potassium carbonate (45.6 g, 0.33 mol) in dry DMF (250 mL) was stirred at 40° C. for minutes. Allyl bromide (5.20 mL, 0.06 mol) was added and the reaction was stirred overnight. The reaction mixture was partitioned between ethyl acetate and 0.2N HCl. The organic layer was washed twice with water, then dried over sodium sulfate. The organic layer was filtered and evaporated to an oil which was chromatographed over silica gel with hexane/ethyl acetate (4:1) to afford 4-allyloxyphenol.
後処理
- customThe reaction mixture was partitioned between ethyl acetate and 0.2N HCl
- washThe organic layer was washed twice with water
- dry with materialdried over sodium sulfate
- filtrationThe organic layer was filtered
- customevaporated to an oil which
- customwas chromatographed over silica gel with hexane/ethyl acetate (4:1)
出典と根拠
- ORDレコード
- ord-8bf6c6150ef04d398fbae183c9b71ec1
- 出典データセット
- uspto-grants-1999_12
- 特許番号
- US06008237
反応ノート
読み込み中…