Water → 6-benzyloxy-2,2-dimethyl-2H-chromen

HRID 613436

反応式

HRID 613436 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[O:15][C:14]([CH3:20])([CH3:19])[CH2:13][CH:12]2O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1(C)C=CC=CC=1>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[O:15][C:14]([CH3:20])([CH3:19])[CH:13]=[CH:12]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 108698276-Benzyloxy-2,2-dimethylchroman-4-ol

生成物 1

HCID 109015466-benzyloxy-2,2-dimethyl-2H-chromen収率 84.4%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 9.6 g (33.8 mmol) of 6-benzyloxy-2,2-dimethylchroman-4-ol and 0.2 g of p-toluenesulfonic acid in 85 ml of toluene was heated under reflux on a water separator for 1 h. After cooling, the mixture was washed twice with sodium bicarbonate solution, dried over magnesium sulfate and concentrated i. vac., giving 7.6 g of 6-benzyloxy-2,2-dimethyl-2H-chromen.

後処理

  1. temperatureAfter cooling
  2. washthe mixture was washed twice with sodium bicarbonate solution
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated i

出典と根拠

ORDレコード
ord-9a35112c0a6d4d98abb3bbe4701f6622
出典データセット
uspto-grants-1999_12
特許番号
US06008245

関連ノート

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