Triethylamine → Ethyl 8-aminoquinoline-3-carboxylate
反応式
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[C:7]2Cl.C(N(CC)CC)C.[H][H]>[Pd].O1CCOCC1>[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:7]2参加物
6
実験手順
A mixture of 8-amino-4-chloro-3-ethoxycarbonylquinoline (45 mg), triethylamine (0.026 ml) and 10%o palladium on carbon (15 mg) in dioxane was stirred for 7 hours at ambient temperature under 3 atmospheric pressure of hydrogen. Insoluble material was filtered off and the filtrate was concentrated in vacuo. The residue was purified by column chromatography on silica gel (ethyl acetate-dichloromethane) to give 8-amino-3-ethoxycarbonylquinoline (24.5 mg).
後処理
- filtrationInsoluble material was filtered off
- concentrationthe filtrate was concentrated in vacuo
- customThe residue was purified by column chromatography on silica gel (ethyl acetate-dichloromethane)
出典と根拠
- ORDレコード
- ord-0dfc0bce7dc54ab9945cc7f95e7730a3
- 出典データセット
- uspto-grants-1999_12
- 特許番号
- US06008230
反応ノート
読み込み中…