Hydrochloric Acid → 4-Amino-8-(2,6-dichlorobenzoylamino)quinoline

HRID 613576ノート

反応式

HRID 613576 の反応式
[Cl:1][C:2]1[CH:40]=[CH:39][CH:38]=[C:37]([Cl:41])[C:3]=1[C:4]([NH:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[N:15]=[CH:14][CH:13]=[C:12]2[N:17]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:5].Cl.[OH-].[Na+]>C(O)(=O)C>[NH2:17][C:12]1[C:11]2[C:16](=[C:7]([NH:6][C:4](=[O:5])[C:3]3[C:2]([Cl:1])=[CH:40][CH:39]=[CH:38][C:37]=3[Cl:41])[CH:8]=[CH:9][CH:10]=2)[N:15]=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 195929798-(2,6-Dichlorobenzoylamino)-4-[(triphenylphosphoranylidene)amino]quinoline

生成物 1

HCID 195925244-Amino-8-(2,6-dichlorobenzoylamino)quinoline収率 100.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
130 °C

実験手順

A mixture of 8-(2,6-dichlorobenzoylamino)-4-[(triphenylphosphoranylidene)amino]quinoline (310 mg), 6N hydrochloric acid (5 ml) and acetic acid (5 ml) was heated for 3 hours at 130° C. After cooling, the mixture was neutralized with 6N sodium hydroxide solution, and the insoluble material was collected by filtration. The residue was recrystallized from ethyl acetate to give 4-amino-8-(2,6-dichlorobenzoylamino)quinoline (174 mg).

後処理

  1. temperatureAfter cooling
  2. filtrationthe insoluble material was collected by filtration
  3. customThe residue was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-d2585a3889fd4f3a9d430e42359e0a3e
出典データセット
uspto-grants-1999_12
特許番号
US06008230

反応ノート

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