Imidazole → 8-Hydroxy-4-(1H-imidazol-yl)-2-methylquinoline
反応式
Cl[C:2]1[C:11]2[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:13])[CH:3]=1.[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1.C(Cl)(Cl)Cl.C(=O)(O)[O-].[Na+]>O1CCOCC1>[OH:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[C:4]([CH3:13])[CH:3]=[C:2]2[N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1参加物
6
実験手順
The solution of 4-chloro-8-hydroxy-2-methylquinoline (2.0 g), imidazole (3.52 g) in dioxane (20 ml) was refluxed for 18 hours. The cooled reaction mixture was added chloroform and aqueous sodium bicarbonate solution. The organic layer was washed with water, dried over magnesium sulfate and evaporated in vacuo. The residue was crystallized from ether to give 8-hydroxy-4-(imidazol-1-yl)-2-methylquinoline (1.99 g) as colorless crystals.
後処理
- customThe cooled reaction mixture
- washThe organic layer was washed with water
- dry with materialdried over magnesium sulfate
- customevaporated in vacuo
- customThe residue was crystallized from ether
出典と根拠
- ORDレコード
- ord-5853b344900c46549b80e590f516101e
- 出典データセット
- uspto-grants-1999_12
- 特許番号
- US06008229
反応ノート
読み込み中…