Pyridine → 8-Acetoxy-2-methylimidazo[1,2-a]pyridine

HRID 613617

反応式

HRID 613617 の反応式
[OH:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH3:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13].N1C=CC=CC=1>ClCCl>[C:12]([O:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH3:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1)(=[O:14])[CH3:13]

参加物

5

反応物 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 8209532-Methylimidazo[1,2-a]pyridin-8-ol

生成物 1

HCID 183219268-Acetoxy-2-methylimidazo[1,2-a]pyridine収率 102%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 8-hydroxy-2-methylimidazo[1,2-a]pyridine (10 g), acetic anhydride (10.3 g) and pyridine (10.7 g) in anhydrous dichloromethane (100 ml) was stirred for 1 hour at ambient temperature and allowed to stand overnight. The 30 mixture was washed with water, and the organic layer was separated. The aqueous layer was neutralized with sodium bicarbonate and extracted with chloroform. The combined organic layers were washed with saturated sodium bicarbonate solution, dried over magnesium sulfate and evaporated in vacuo to give 8-acetoxy-2-methylimidazo[1,2-a]pyridine (13.1 g) as oil.

後処理

  1. waitto stand overnight
  2. washThe 30 mixture was washed with water
  3. customthe organic layer was separated
  4. extractionextracted with chloroform
  5. washThe combined organic layers were washed with saturated sodium bicarbonate solution
  6. dry with materialdried over magnesium sulfate
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-c73c14e2cff948938980e69f1e0397eb
出典データセット
uspto-grants-1999_12
特許番号
US06008229

関連ノート

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