Hydrochloric Acid → 3-Bromo-8-hydroxy-2-methylimidazo[1,2-a]pyridine
反応式
C([O:4][C:5]1[C:6]2[N:7]([C:11]([Br:15])=[C:12]([CH3:14])[N:13]=2)[CH:8]=[CH:9][CH:10]=1)(=O)C.[OH-].[Na+].Cl>CO>[Br:15][C:11]1[N:7]2[CH:8]=[CH:9][CH:10]=[C:5]([OH:4])[C:6]2=[N:13][C:12]=1[CH3:14]参加物
5
実験手順
To a solution of 8 -acetoxy-3-bromo-2-methylimidazo[1,2-a]pyridine (235 mg) in methanol (2.5 ml) was added 1N sodium hydroxide solution (2.0 ml) under ice-cooling, and the mixture was stirred for 30 minutes at the same temperature. The mixture was neutralized with 1N hydrochloric acid, and the resulting precipitates were collected by filtration and washed with water to give 3-bromo-8-hydroxy-2-methylimidazo[1,2-a]pyridine (150 mg) as brown powder.
後処理
- temperaturecooling
- customthe resulting precipitates
- filtrationwere collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-fcb8a08985eb4b4f9663ae54a94945aa
- 出典データセット
- uspto-grants-1999_12
- 特許番号
- US06008229
反応ノート
読み込み中…