Hydrochloric Acid → D-phenylalanine hydrochloride

HRID 613796

反応式

HRID 613796 の反応式
[NH2:1][C@@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:13]>>[ClH:13].[NH2:1][C@@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 71567D-Phenylalanine

生成物 1

HCID 13000988D-phenylalanine hydrochloride

実験手順

The residual mother liquor weighing 1359 g which contained 185.6 mmol of D-phenylalanine having an optical purity of 93.6% was adjusted to pH 0.5 with concentrated hydrochloric acid, and the resulting solution was concentrated until crystals began to precipitate to carry out crystallization. The aqueous slurry containing the crystals was filtered by suction at room temperature to give 74.8 mmol of glossy and grayish crystals of D-phenylalanine hydrochloride having an optical purity of 99.2%. The mother liquor contained 110.8 mmol of D-phenylalanine having an optical purity of 89.7%.

後処理

  1. concentrationthe resulting solution was concentrated until crystals
  2. customto precipitate
  3. customcrystallization
  4. additionThe aqueous slurry containing the crystals
  5. filtrationwas filtered by suction at room temperature

出典と根拠

ORDレコード
ord-5ac1dc546b954f75a397be33b350b0c6
出典データセット
uspto-grants-1999_12
特許番号
US06008403

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