Sodium Hydroxide → 2,3-Difluorotoluene
反応式
Cl[C:2]1([F:11])[C:7](F)([F:8])[CH2:6][CH:5]=[CH:4][CH:3]1[CH3:10].[OH-].[Na+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1>[F:11][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:10]参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a stirred solution of 4-chloro-3-methyl-4,5,5-trifluorocyclohexene of 58.6 g prepared in Example 12 was added 2.5 g of benzyltriethylammonium chloride, and then the reaction mixture was heated to 80° C. followed by slowly adding 240 g of 50% aqueous sodium hydroxide solution for 1 hour. The reaction mixture was stirred for additional 3 hours at 80° C., and then the resultant was purified by steam distillation followed by separating the aqueous layer. The organic layer was dried with calcium chloride, and then 32.3 g of the desired product was collected by fractional distillation as a colorless liquid.
後処理
- distillationthe resultant was purified by steam distillation
- customby separating the aqueous layer
- dry with materialThe organic layer was dried with calcium chloride
- distillation32.3 g of the desired product was collected by fractional distillation as a colorless liquid
出典と根拠
- ORDレコード
- ord-a2d78162ed9e475fbe4915d074836cd7
- 出典データセット
- uspto-grants-1999_12
- 特許番号
- US06008407
反応ノート
読み込み中…