Water → N-Ethyl-N-(4-methyl-1,3-oxazol-2-yl)acetamide

HRID 613991ノート

反応式

HRID 613991 の反応式
[CH2:1]([NH:3][C:4](=[O:6])[CH3:5])[CH3:2].[H-].[Na+].[CH3:9][C:10]1[N:11]=[C:12](S(CC2C=CC=CC=2)=O)[O:13][CH:14]=1.O>CN(C)C=O>[CH2:1]([N:3]([C:12]1[O:13][CH:14]=[C:10]([CH3:9])[N:11]=1)[C:4](=[O:6])[CH3:5])[CH3:2]

参加物

6

反応物 4

HCID 962WaterHCID 12253EthylacetamideHCID 24758Sodium hydrideHCID 213297224-Methyl-2-(phenylmethanesulfinyl)-1,3-oxazole

生成物 1

HCID 21323613N-Ethyl-N-(4-methyl-1,3-oxazol-2-yl)acetamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
50 °C

実験手順

N-Ethyl-acetamide (1.18 g, 0.0135 m) in dry dimethylformamide (10 ml) was stirred at room temperature under nitrogen during the portionwise addition of 50% sodium hydride/oil dispersion (0.65 g, 0.0135 m). After the addition, the mixture was warmed to 50° C. and then 4-methyl-2-phenylmethylsulphinyloxazole (3.0 g, 0.0135 m) was added. The mixture was stirred at 50° C. for 5 hours and then hydrolysed with water. The solvent was evaporated in vacuo and the residue extracted with diethyl ether. Column chromatography on silica using ether gave a pale yellow oil which gave the title product as a colourless oil on distillation, b.p. 50°-51° C./0.05 mm.

後処理

  1. additionAfter the addition
  2. customThe solvent was evaporated in vacuo
  3. extractionthe residue extracted with diethyl ether
  4. customgave a pale yellow oil which

出典と根拠

ORDレコード
ord-3e42288b8b19462a8df9aaeeb0112ee9
出典データセット
uspto-grants-1979_03
特許番号
US04143047

反応ノート

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