Ammonia → N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyrimidinyl)urea

HRID 614321ノート

反応式

HRID 614321 の反応式
[NH3:1].Cl.[CH:3]([N:6]([CH:27]([CH3:29])[CH3:28])[CH2:7][CH2:8][N:9]([C:19]1[N:24]=[C:23]([CH3:25])[CH:22]=[C:21]([CH3:26])[N:20]=1)[C:10](=O)[O:11]C1C=CC=CC=1)([CH3:5])[CH3:4]>O1CCCC1>[CH:3]([N:6]([CH:27]([CH3:29])[CH3:28])[CH2:7][CH2:8][N:9]([C:19]1[N:24]=[C:23]([CH3:25])[CH:22]=[C:21]([CH3:26])[N:20]=1)[C:10]([NH2:1])=[O:11])([CH3:5])[CH3:4]

参加物

4

反応物 2

HCID 222AmmoniaHCID 21329151phenyl N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyrimidinyl)carbamate hydrochloride

生成物 1

HCID 23349873N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyrimidinyl)urea

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Concentrated ammonia (10 ml) is added to a solution of phenyl N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyrimidinyl)carbamate hydrochloride (7.33 g., 0.018 mole) in 50 ml of tetrahydrofuran and the mixture is allowed to stand for twenty-four hours. It is concentrated, water and chloroform are added to the residue, the chloroform is separated and concentrated. Crystallization of the residue from hexane yields N-(2-diisopropylaminoethyl)-N-(4,6-dimethyl-2-pyrimidinyl)urea melting at 134°-136° C.

後処理

  1. waitto stand for twenty-four hours
  2. concentrationIt is concentrated
  3. additionwater and chloroform are added to the residue
  4. customthe chloroform is separated
  5. concentrationconcentrated
  6. customCrystallization of the residue from hexane

出典と根拠

ORDレコード
ord-b8c3ecceeea549b7bea655d628c4b316
出典データセット
uspto-grants-1979_03
特許番号
US04144338

反応ノート

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