Butyl isocyanate → HCID 178449847、化合物

HRID 614343ノート

反応式

HRID 614343 の反応式
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([N:10]3[C:14]4=[N:15][CH:16]=[CH:17][CH:18]=[C:13]4[NH:12][C:11]3=[O:19])=[CH:4][C:3]=2[O:2]1.[CH2:20]([N:24]=[C:25]=[O:26])[CH2:21][CH2:22][CH3:23].C1OC2C=CC(N3C4=NC=CC=C4NC3=O)=CC=2[O:28]1.C(C(N)=O)CCC>C(COC)OC>[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([N:10]3[C:14]4=[N:15][CH:16]=[CH:17][CH:18]=[C:13]4[NH:12][C:11]3=[O:19])=[CH:4][C:3]=2[O:2]1.[CH2:20]([N-:24][C:25]([OH:28])=[O:26])[CH2:21][CH2:22][CH3:23]

参加物

5

反応物 3

HCID 8110Butyl isocyanateHCID 119617392H-Imidazo[4,5-b]pyridin-2-one, 3-(1,3-benzodioxol-5-yl)-1,3-dihydro-HCID 131711457HCID 131711457、化合物

生成物 1

HCID 178449847HCID 178449847、化合物

試薬・触媒・溶媒 1

HCID 80711,2-Dimethoxyethane溶媒

実験手順

A suspension of 1.2 g. of 1,3-dihydro-3-(3,4-methylenedioxyphenyl)imidazo[4,5-b]pyridin-2-one in 75 ml. of dry dimethoxyethane was treated with 1 g. of n-butyl isocyanate and refluxed until solution was complete. The solution was filtered and evaporated to near dryness and diluted with petroleum ether. The precipitate was recrystallized from 30 ml. of ethanol by addition of water to give 400 mg. of 1,3-dihydro-3-(3,4-methylenedioxyphenyl)-2-oxoimidazo[4,5-b]pyridine-1-n-butylcarboxamide,. m.p. 129°-130° C.

後処理

  1. additionA suspension of 1.2 g
  2. filtrationThe solution was filtered
  3. customevaporated
  4. additiondiluted with petroleum ether
  5. customThe precipitate was recrystallized from 30 ml
  6. additionof ethanol by addition of water
  7. customto give 400 mg

出典と根拠

ORDレコード
ord-4c0556a970b14a9f9ae67bf663002da8
出典データセット
uspto-grants-1979_03
特許番号
US04144341

反応ノート

読み込み中…