1,2-Ethanediamine, N1-phenyl- → 1-[2-Hydroxy-3-(2-methoxyphenyloxy)-propyl]-4-(2-anilino-ethylamino)-piperidine

HRID 614363ノート

反応式

HRID 614363 の反応式
[OH:1][CH:2]([CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20])[CH2:3][N:4]1[CH2:9][CH2:8][C:7](=O)[CH2:6][CH2:5]1.[NH2:21][CH2:22][CH2:23][NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[H][H]>CO.[Pt]>[OH:1][CH:2]([CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20])[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:21][CH2:22][CH2:23][NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:6][CH2:5]1

参加物

6

反応物 3

HCID 742701,2-Ethanediamine, N1-phenyl-HCID 233473441-[2-Hydroxy-(2-methoxyphenyloxy)-propyl]-piperidin-4-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 233473391-[2-Hydroxy-3-(2-methoxyphenyloxy)-propyl]-4-(2-anilino-ethylamino)-piperidine

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 887Methanol溶媒

実験手順

A solution of 16.7 g of 1-[2-hydroxy-3-(2-methoxyphenyloxy)-propyl]-piperidine-4-one and 10.5 g of N-(2-aminoethyl)-aniline in 250 ml of methanol, with the addition of 1 g of a 5% platinum on charcoal catalyst is hydrogenated at room temperature and under normal pressure until 1 molar equivalent of hydrogen has been taken up. The catalyst is thereafter removed by filtration and the filtrate is concentrated under reduced pressure. The residue is freed from excess starting material in a bulb tube at 0.3 mm Hg and 120° C oven temperature to yield as distillation residue 1-[2-hydroxy-3-(2-methoxyphenyloxy)-propyl]-4-(2-anilino-ethylamino)-piperidine, which can be used without further purification.

後処理

  1. customThe catalyst is thereafter removed by filtration
  2. concentrationthe filtrate is concentrated under reduced pressure
  3. customThe residue is freed from excess starting material in a bulb tube at 0.3 mm Hg and 120° C oven temperature

出典と根拠

ORDレコード
ord-19ba23c697d24fa38c5f7227883ba5e1
出典データセット
uspto-grants-1979_03
特許番号
US04144344

反応ノート

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